Effects of fish oil emulsion on severe acute pancreatitis patients

• Research type

  Research Study

• Full title

  Randomised controlled trial on the effects of parenteral fish oil emulsion in patients with severe acute pancreatitis

• IRAS ID

  45750

• Contact name

  Ashley Dennison

• Sponsor organisation

  Research and Innovation

• Eudract number

  2010-018660-16

• ISRCTN Number

  n/a

• Clinicaltrials.gov Identifier

  n/a

• Research summary

  Studies on animals and human cell lines described the effect of Omega 3 fish oil on inflammation. They showed that supplementing cells with Omega 3 resulted in controlling the severe inflammation and improving the outcome. This research will look at the effects of supplementing Omega 3 fish oil to patients with severe acute pancreatitis (severe inflammation of the pancreas). It involves supplying fish oil as emulsion intravenously for patients with severe inflammation of the pancreas who are admitted to Leicester General Hospital wards. The patients with severe inflammation of the pancreas will be prospectively randomised in a blind fashion and divided into either a study group who will receive (Lipidem which contains omega 3) or a control group which will receive (Lipofundin nutritional lipid with no omega 3 supplement). The usual clinical care will continue as normal and will not be affected or altered. Each patient will receive the emulsion daily untill they are sought to be fit for discharge by the patient's own medical team or for a maximum of SEVEN days. The aim is to determine whether there is an improvement in the outcome in this group of ill patients some of whom have significant mortality. If a significant improvement is indicated by a reduced mortality or reduced complications or reduced hospital stay it will be a significant advance in the care of these patients and would have an enormous impact on future clinical practice.

• REC name

  East Midlands - Leicester South Research Ethics Committee

• REC reference

  10/H0402/15

• Date of REC Opinion

  22 Apr 2010

• REC opinion

  Further Information Favourable Opinion