Effectiveness of Voriconazole in Aspergillus associated asthma

• Research type

  Research Study

• Full title

  Study of the effectiveness of Voriconazole in the treatment of Aspergillus fumigatus associated asthma

• IRAS ID

  12679

• Contact name

  Andrew Wardlaw

• Sponsor organisation

  University Hospitals of Leicester NHS Trust

• Eudract number

  2009-011452-21

• ISRCTN Number

  42366088

• Research summary

  In a subset of patients with asthma, usually those with more severe disease, their airways are colonised with a mould called Aspergillus fumigatus (AF). This can cause a severe allergic reaction leading to marked eosinophilic airway inflammation and a tendency for severe exacerbations. The aim of this study is to determine if a potent anti-fungal agent, voriconazole, can eradicate the colonisation and if this leads to an improvement in asthma control

• REC name

  East Midlands - Leicester South Research Ethics Committee

• REC reference

  09/H0402/63

• Date of REC Opinion

  31 Jul 2009

• REC opinion

  Further Information Favourable Opinion