Effectiveness of GANfort® in reducing intraocular pressure in glaucoma

• Research type

  Research Study

• Full title

  Effectiveness of GANfort® in reducing intraocular pressure in patients presenting with significantly elevated intraocular pressure

• Sponsor organisation

  Nottingham University Hospital NHS Trust

• Eudract number

  2007-001046-41

• ISRCTN Number

  n/a

• Clinicaltrials.gov Identifier

  n/a

• Research summary

  Elevated intraocular pressure (IOP) is the only treatable risk factor in patients with glaucoma and reduction of IOP reduces the risk of visual loss. In some patients presenting with glaucoma the intraocular pressure is very significantly raised and the use of a single drop medication alone is not sufficient to lower pressure adequately. Traditionally in these patients a single drop would be started first and at a later stage a second drop added to achieve adequate control. The aim of this research is to see how effective using two drops together is as the initial treatment in this group of patients with very significantly raised IOP.The proposed drop GANfort is currently available for second line treatment of patients with glaucoma and is a combination of two commonly used drops (timolol and bimatoprost). In addition to the improved pressure lowering associated with two drop treatment it is expected that the use of a combination drop will also improve compliance as only one bottle of medication is required and reduce the risk of allergy as half the dose of preservative will be used (as opposed to two bottles).

• REC name

  East Midlands - Nottingham 2 Research Ethics Committee

• REC reference

  08/H0408/136

• Date of REC Opinion

  11 Dec 2008

• REC opinion

  Further Information Favourable Opinion