EFFECT SITE TARGETED PROPOFOL FOR ANAESTHESIA IN CHILDREN

• Research type

  Research Study

• Full title

  VALIDATION OF AN EFFECT-SITE TARGETED PROPOFOL INFUSION FOR ANAESTHESIA IN CHILDREN

• IRAS ID

  31082

• Eudract number

  2009-014568-21

• ISRCTN Number

  ISRCTN63387871

• Research summary

  Updated information is now available to improve one of the commonly used methods of providing general anaesthesia using an infusion of the anaesthetic drug Propofol. We aim to validate this improved technique, which allows tailoring of the dose to the child's age, to confirm the infusion is accurate and safe in clinical practice. This technique uses a computer-controlled infusion device which is programmed with software appropriate to the child's age and weight. This makes allowances for the differences which occur with age and development in the handling of propofol by the body. The software has the added advantage of predicting the brain concentration of propofol which should allow more rapid production of anaesthesia and more accurate dose control. By also using an electronic monitor to measure the depth of anaesthesia, we hope to calculate the accuracy of the software in predicting the brain concentration. The results should help anaesthetists to give enough propofol to ensure adequate anaesthesia whilst avoiding too much propofol which can have side effects and cause slow recovery.

• REC name

  North of Scotland Research Ethics Committee 1

• REC reference

  11/AL/0215

• Date of REC Opinion

  7 Sep 2011

• REC opinion

  Further Information Favourable Opinion