Effect of VLCD-RYGB on weight, LBM and MPS. v2.0
Research type
Research Study
Full title
Exploring the immediate and short-term effect of very low calorie diet (VLCD) and Roux-en-Y Gastric Bypass (RYGB) operation on weight loss, lean body mass (LBM) and muscle protein synthesis (MPS) in obese patients.
IRAS ID
226892
Contact name
Iskandar Idris
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Bariatric surgery particularly the Roux-en Y gastric bypass (RYGB) operation has been shown to achieve a large and sustained improvement in insulin and pancreas function and possibly ‘cure’ type 2 diabetes. The benefits of RYGB are observed early before substantial weight loss. It has been proposed that the long-term improvements are related to a reduction in fat mass, but the mechanisms for the early improvements remain unclear. In addition, caloric restriction via a very low calorie diet (VLCD; typically, <600kcal/day), is mandatory to all patients for a 2 to 3 weeks period before RYGB in order to reduce liver size and help makes bariatric surgery easier to perform.
Weight loss from both RYGB and VLCD result in significant lean body mass (LBM) losses, including skeletal muscle. This is important since skeletal muscle plays an important role as the largest site of glucose control and represents a vast protein store.
The purpose of this study is to investigate the changes in the rate of muscle protein synthesis, muscle protein breakdown and muscle structure changes between different phases of VLCD and RYGB operation. We hope that our findings would help us better understand the underlying process so we can develop strategies to attenuate LBM losses during a period of energy deficit and surgical insult.
To help our aims above, we will recruit 12 volunteers that fit the criteria. Each volunteer will have 7 visits to our research unit for a serial blood test, saliva collection, muscle biopsies and fat biopsies before and after the VCLD and RYGB procedures. Investigators will try their best to ensure as many of the visits will coincide with patients routine hospital visit. They also will be provided with solutions to drink to help to trace new muscle tissues.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
17/YH/0305
Date of REC Opinion
8 Nov 2017
REC opinion
Further Information Favourable Opinion