Effect of sterilisation & storage on extracted teeth (in vitro study)
Research type
Research Study
Full title
Studying of the antibacterial effectiveness and effect of sterilization and storage on dental hard tissue of extracted teeth (in-vitro comparative study).
IRAS ID
169781
Contact name
Suhad Al-nasrawi
Contact email
Sponsor organisation
University of Manchester
Research summary
This study is a laboratory research, will be conducted to recognised effective sterilisation/storage methods that cause minimal physical and chemical alterations to the dental hard tissue. One of the most significant current discussions in Dentistry is the sterilization of extracted human teeth (EHT). They are frequently used in dental education to learn the pre-clinical skill. In addition, they are used in in-vitro research to investigate treatment and materials which may improve the clinical performance.
EHT represents a potential source of cross-infection because they are heavily loaded with bacteria, viruses and their toxin, so it is important to identify an effective sterilization method. Unfortunately, sterilization of the EHT has many challenges because of the difficulties in preserving their structures that may be altered or even damaged by this process. The preservation of the dental substrate represents an important requirement which has a great impact on the validity of research results and the educational outcomes. There is no standardised sterilisation and storage methods and different method end with the different incomparable result with a different effect on tooth structure. All that represent important requirement to find standardised effective sterilisation and storage method which can preserve tooth structure to give valid educational and research results.
This study will be a laboratory study will be conducted on surplus and anonymous extracted teeth which will be undergone physical and chemical test to analyse the effect of the sterilisation and storage methods on the dental hard tissue. The study will be conducted at the faculty of the medical and human sciences and may require two years to be completed.REC name
London - Harrow Research Ethics Committee
REC reference
15/LO/1545
Date of REC Opinion
30 Sep 2015
REC opinion
Further Information Favourable Opinion