Effect of Sodium Hyaluronate Eyedrop on Contact Lens Wettability
Research type
Research Study
Full title
Effect of Sodium Hyaluronate Eyedrop on Contact Lens Wettability
IRAS ID
237670
Contact name
Kishan Patel
Contact email
Sponsor organisation
CooperVision, Inc.
Duration of Study in the UK
0 years, 7 months, 2 days
Research summary
Sodium hyaluronate (Hyaluronate Acid (HA) eyedrops are used extensively in patients complaining of dry eye, including symptomatic contact lens wearers. Cross-linked HA structure eyedrops are believed to have greater effectivity than non-cross-linked HA but may also produce temporary blur vision upon instillation. The purpose of this study is to compare the effect of cross-linked hyaluronic Acid (HA) to non-cross- linked HA eyedrop on contact lens on eye wettability in symptomatic lens wearers. Specifically, how much change in tear film characteristics is produced and how long the improvement lasts post instillation. The effect on lens comfort and vision will be evaluated. Twenty existing daily disposable contact lens wearers with discomfort/dry eye symptoms will be enrolled. There will be three study visits over a three-week period. Participants will use both eyedrops (test: cross-linked HA, control:non-cross-linked HA) in a randomized order. The eyedrops are CE marked and will be administered at the study site only. Each participant will have a single drop of the study eyedrop instilled in each eye. The participants will be monitored for three hours post instillation of the study eyedrop at the study site. Both participant and investigator will be masked.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
17/NW/0659
Date of REC Opinion
15 Nov 2017
REC opinion
Further Information Favourable Opinion