Effect of revascularisation on macro/micro and endothelial function
Research type
Research Study
Full title
THE EFFECT OF LOWER LIMB REVASCULARISATION ON THE MACRO/MICROCIRCULATION AND ENDOTHELIAL FUNCTION IN PATIENTS WITH CRITICAL LIMB ISCHEMIA. A PILOT STUDY OF PATIENTS UNDERGOING PERIPHERAL ARTERIAL REVASCULARISATION
IRAS ID
261461
Contact name
Sodabeh Khosravi
Contact email
Sponsor organisation
Imperial Collge London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
0 years, 4 months, 30 days
Research summary
This is a single centre pilot study of patients suffering from critical limb ischemia (CLI), to investigate the effect of lower limb revascularisation procedure on microvascular and macrovascular flow profiles and systemic endothelial function.
Critical limb ischemia is a severe form of peripheral arterial disease caused by occlusion of arteries and obstruction of blood flow to lower extremities. It is defined as ischemic rest pain, ulceration or gangrene.Further work on this topic may allow us to better understand whether the degree of improvement in blood flow after revascularisation for CLI may predict wound healing and changes in endothelial function.
In this initial pilot study, we aim to achieve a better understanding of degree of change, if any, that may occur to macro and micro vascular flow profiles and endothelial function after revascularisation procedures in patients with CLI.
REC name
North West - Greater Manchester Central Research Ethics Committee
REC reference
19/NW/0186
Date of REC Opinion
25 Mar 2019
REC opinion
Favourable Opinion