Effect of peri operative analgesia in total hip replacement
Research type
Research Study
Full title
A Two Phase Prospective Randomized Control Trial of Infiltrated Periarticular Multimodal Analgesia following Primary Total Hip Replacement
IRAS ID
26716
Contact name
Richard E Field
Eudract number
2009-013645-29
ISRCTN Number
Not Submitted
Research summary
This is a two phased randomised controlled trial determining the efficacy of wound infiltration in patients undergoing elective total hip replacement (THR). In phase 1, four different combinations of a local anaesthetic(Ropivocaine), a non steroidal anti- inflammatory drug (ketorolac) and a vaso-constrictor (Adrenaline) will be used with a fifth control group receiving a placebo (Saline ). Adult patients undergoing primary THR are eligible; exclusions are known contraindications to any of the three drugs or the existence or comorbidities that may adversely affect their post-operative recovery. The first dose is instilled by the surgeon intra-operatively in the wound, a further two doses are administered through a percutaneous intra-articular 19G catheter, 10 and 20 hours after the operation. The catheter is withdrawn after the second top-up. This will document the best combination of medication in achieving adequate post operative pain control. In phase 2, the best combination of pain relief as evident in phase 1 will be used to determine the number of post operative doses required for pain control after total hip replacement. This study will establish the most effective protocol for pain relief with wound infiltration in total hip replacement. This involves recruitment of 250 patients for phase 1 and 200 patients for phase 2.The patients will be monitored during their in patient stay and a radiograph of the operated hip will be obtained six months post operatively.
REC name
London - Hampstead Research Ethics Committee
REC reference
09/H0720/98
Date of REC Opinion
23 Jul 2009
REC opinion
Favourable Opinion