Effect of implant surface on bone regeneration

• Research type

  Research Study

• Full title

  Effect of implant surface material and topography on bone regeneration: A two-centre, parallel-group, pilot study.

• IRAS ID

  321927

• Contact name

  Nikolaos Donos

• Contact email

  n.donos@qmul@ac.uk

• Sponsor organisation

  Queen Mary University of London

• Clinicaltrials.gov Identifier

  NCT05890469

• Clinicaltrials.gov Identifier

  NCT05890469, NCT number

• Duration of Study in the UK

  2 years, 0 months, 2 days

• Research summary

  Although dental implants have been on the market for several years and they are routinely used to replace single/multiple missing teeth with a high success rate. However, there is still a limited number of studies comparing hydrophilic titanium and zirconia implants. In addition, there is no data available on the signalling pathways and the expression of healing biomarkers involved in the early stages of osseointegration around zirconia surface implants placed with guided bone regeneration (GBR).
  In this study we assess the differences in the expression of inflammatory, angiogenesis and osseous biomarkers of PICF and saliva at 1, 3, 7, 15 and 30 days after the placement of hydrophilic titanium or zirconia surface dental implants with simultaneous GBR.
  This study aims 1) to describe and compare the early wound healing molecular pathways, and the 2) vascularization patterns of mucosal tissues after the placement of hydrophilic titanium or zirconia implants with simultaneous guided bone regeneration (GBR).

  This is a two-center prospective observational study with two parallel study groups and will consist of 10-11 visits approximately around a period of 14 months. The study will take place at the Centre for Oral Clinical Research (COCR), at the Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Royal London Dental Hospital - Barts Health NHS Trust (main centre), United Kingdom and at Clinic of Reconstructive Dentistry, University of Zurich, Zurich, Switzerland, in accordance with local guidelines and procedures/interventions detailed below.

• REC name

  West Midlands - Black Country Research Ethics Committee

• REC reference

  23/WM/0173

• Date of REC Opinion

  22 Sep 2023

• REC opinion

  Further Information Favourable Opinion