Effect of Hyaluronic Acid on Knee Biomechanics
Research type
Research Study
Full title
Effect of the Intraarticular Injection of Hyaluronic Acid on Knee Biomechanics at Different Walking Speeds in Patients with Osteoarthritis
IRAS ID
129620
Contact name
Ambreen Chohan
Contact email
Research summary
With an ageing population the incidence of osteoarthritis (OA) is expected to rise and subsequently, so will the cost of its management. With the cost of a total knee replacement being in the many thousands and the symptoms associated with OA causing an inability to perform simple daily tasks, research into the conservative management of the disease is of paramount importance.
Hyaluronic Acid (HA) is used widely for the short term management of symptomatic OA. It is frequently advertised as having the ability to delay the need for joint replacement surgery in both minor and major joints as well as having the ability to improve not only pain and disability but also “knee function”.
The aim of this study is to identify the effects of the in joint hyaluronic acid (in the form of Synvisc-One®) injection in patients with moderate to severe osteoarthritis of the knee.
The study will assess whether or not hyaluronic acid improves the morbidity (pain, stiffness and immobility) associated with osteoarthritis and whether or not it improves knee movement in such patients. Our goal is to better the understanding of the non-surgical treatment of osteoarthritis and thus improve patient quality of life, delay disease progression and delay the need for surgery.
Specifically we will assess:
•Changes in patient reported outcome measures (symptoms and functionality) using the Knee injury and Osteoarthritis Outcome Score (KOOS)
•Changes in knee biomechanics (movement and control).REC name
North West - Preston Research Ethics Committee
REC reference
14/NW/0021
Date of REC Opinion
5 Mar 2014
REC opinion
Further Information Favourable Opinion