Effect of high- and low-fructose diets on intestinal fat production.
Research type
Research Study
Full title
The effect of fructose on intestinal triglyceride production and de novo fatty acid synthesis in humans.
IRAS ID
167084
Contact name
Simon Steenson
Contact email
Sponsor organisation
University of Surrey
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Recent evidence suggests that fructose, one of the main sugars consumed in the diet, increases the amount of circulating triglyceride (fat) in the blood, both in the fasted state, as well as post-prandially (after a meal). Raised triglyceride levels in the blood are an established risk factor for cardiovascular disease (CVD - e.g. heart attack and stroke). Although much research has focussed on the effects of fructose on the liver, where it increases fat production, there is emerging evidence from human and animal studies that the intestine may also play an important role. The current study aims to establish whether a diet specifically high in fructose can lead to an increase in fat production in the intestine.
REC name
London - Surrey Research Ethics Committee
REC reference
15/LO/0891
Date of REC Opinion
15 Jun 2015
REC opinion
Favourable Opinion