Effect of GnRH analogues on BMI in children with precocious puberty
Research type
Research Study
Full title
Effect of Gonadotropin releasing hormone(GnRH)analogues on body mass index in children with precocious/early puberty and patient/parent experience of the treatment
IRAS ID
126268
Contact name
Sanjay Gupta
Contact email
Sponsor organisation
university of Leeds
Research summary
This is a study looking at the the change in BMI for children treated with GnRH analogues for precocious or early puberty.
This is a retrospective case note study. Data will be collected from patients who were commenced on treatment with GnRH analogues between April 2002 and April 2011. All children treated with GnRH analogues for precocious puberty or early puberty and continued on the treatment for at least two years will be included.
After ethical approval, I will provide a patient information leaflet to parent / patients explaining the study along with a consent form and a questionnaire(anonymous) regarding their experience of the treatment.
The auxology data( height and weight with calculated BMI in kilogram/meter square)will be obtained from the database.(Data has been stored in the nordinet database from 2008 onwards,Data prior to 2008 has been stored in a seperate database maintained by the specialist nurse). Target height compared with mid-parental height and projected adult height will also be recorded.
The follow up parameters which I intend to note for each visit will include compliance to medication, weight and height and BMI. I will collect data until the patient is discharged from the clinic.
I will endeavour to measure the patient's current height and weight.
I will compare data at the start of treatment with GnRH analogues, point of completion of treatment and the most recent point of contact/ attainment of adult height (if data available).
The questionnaire response will give an insight into better understanding of patient perception.REC name
London - Brent Research Ethics Committee
REC reference
13/LO/1006
Date of REC Opinion
2 Aug 2013
REC opinion
Further Information Favourable Opinion