Effect of exclusion of bacteremia on antibiotic treatment
Research type
Research Study
Full title
Observational study in critical care to assess if use of a diagnostic test to exclude bactermia would affect clinical decision making
IRAS ID
198903
Contact name
Tabitha Kavoi
Contact email
Sponsor organisation
University College London Hospitals
Duration of Study in the UK
0 years, 9 months, 8 days
Research summary
This is an observational study to compare the performance of Enzymatic Template Generation & Amplification (ETGA) to conventional clinical and microbiological evaluation in determining length of antibiotic treatment in patients in the critical care unit. The test shows with a high degree of certainty the absence of bacteria and fungi in a blood sample. The study will focus on critically ill patients admitted with suspected sepsis, severe pneumonia, and other infections who require critical care assessment and evaluation. With the increasing risk of highly resistant organisms, unecessary use of antibiotics must be kept to a minimum. Although antibiotic treatment will be stopped when clearly not needed there is often a period of uncertainty. None of the indicators used each day are specific to the presence of infection. Hence antibiotics may be given several days longer than needed. The test in this study may aid earlier stopping of antibiotic treatment.
REC name
Wales REC 4
REC reference
16/WA/0264
Date of REC Opinion
21 Sep 2016
REC opinion
Further Information Favourable Opinion