Eepidemiology, clinical features and imaging features of COVID-19
Research type
Research Study
Full title
Retrospective analysis of the epidemiology and clinical features of COVID-19 swab positive patients in relation to their imaging characteristics in a UK District general Hospital
IRAS ID
288443
Contact name
Nicholas R P Barlow
Contact email
Sponsor organisation
The Rotherham NHS Foundation
Clinicaltrials.gov Identifier
34134, Study ref
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Summary of Research
This study seeks to identify the percentage occurrence of chest x ray, CT chest and CT abdomen features of patients with COVID-19 positive swab test results. We also aim to identify the epidemiology and clinical presentation of these patients.There are several published literature in relation to radiographic findings in COVID-19 patients however the majority are focused on CT findings and chest radiograph appearances have been largely neglected. Furthermore the majority of literature has been published from China with minimal studies conducted in the UK. It is possible that there may be variance in symptom presentation globally and by identifying the key symptoms on presentation we hope to correlate this with the current literature to identify any variance. By correlating the clinical presentation with the radiographic findings we also hope to identify whether certain demographics (age and gender) or certain symptoms are more likely to present with radiographic manifestations.
This retrospective study will take place in a single district general hospital in the North of England. All patients who tested positive for COVID-19 on hospital attendance during the period of 01.03.20 and 31.04.20 will be eligible for this study. Epidemiology and clinical data will be collected via the electronic radiographic information systems, whereas x-ray/CT imaging findings will be obtained via access to the local picture archiving and communications system (PACS).
Summary of Results
There was a significant difference in the number of abnormal chest X-rays (CXR) between males and females (p= 0.0086). Within these there were no individual symptoms showing significant differences between the sexes. Consolidation with bilateral, basal and peripheral predominance was all common features. Pleural effusion was seen in 4%. This study corroborates imaging findings from earlier studies in the prevalence of radiographic/CT features. There was no significant difference in symptoms between males and females however there was a significant difference in the number of abnormal imaging between the groups.REC name
Wales REC 6
REC reference
20/WA/0316
Date of REC Opinion
19 Nov 2020
REC opinion
Favourable Opinion