EEG measures of aging and Alzheimer's disease in Down's Syndrome
Research type
Research Study
Full title
Characterising aging effects on EEG indices of neurocognitive processes in adults with Down’s Syndrome: identifying potential markers of Alzheimer’s disease development
IRAS ID
150350
Contact name
Sally Jennings
Contact email
Sponsor organisation
Cambridgeshire and Peterborough Founsation Trust and University of Cambridge (joint sponsors)
Research summary
People with Down’s Syndrome are at increased risk of developing Alzheimer’s disease, and do so at younger ages, compared to the general population. This might be because amyloid is over-produced in Down’s Syndrome and amyloid build-up plays a key role in the development of Alzheimer’s disease. Electroencephalography (EEG) is a technology which records brain activity through electrodes placed on the scalp. EEG is a promising candidate for screening ‘at risk’ populations because it is entirely safe, relatively cheap and undemanding for participants. The aim of this study is to investigate whether EEG has the potential to both measure the effects of aging on the brain and indicate early stages of Alzheimer’s disease, in Down’s Syndrome.
REC name
London - Queen Square Research Ethics Committee
REC reference
14/LO/1411
Date of REC Opinion
4 Sep 2014
REC opinion
Favourable Opinion