ECG Parameters predicting Adverse Events in Congenital Heart Disease
Research type
Research Study
Full title
Testing the Validity of ECG Parameters in Predicting Adverse Outcomes in Congenital Heart Disease.
IRAS ID
250076
Contact name
Louise Coats
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
It has been well established over the past two decades that older children and adults with previous surgery for congenital heart disease (CHD) represent an at-risk population for abnormal heart rhythms (arrhythmias), including ventricular tachycardia (VT), ventricular fibrillation (VF) and sudden cardiac death (SCD)[1, 2]. This risk is believed to be primarily due to a combination of underlying inherent myocardial conduction abnormalities and iatrogenic factors, through the presence of fibrotic scar tissue from reparative surgery.\n\nFollowing surgery, many children with CHD can lead normal lives, although some develop arrhythmias as adults, potentially resulting in sudden cardiac death (SCD). Currently, no single predictive measure exists to detect CHD patients at heightened risk of developing arrhythmias, although candidates are regularly proposed, including QRS prolongation and most recently, the QRS Vector Magnitude (QRSvM).\n\nThis project aims to test the validity of these and other parameters in predicting arrhythmias in the regional population of CHD patients managed at the Freeman Hospital, Newcastle upon Tyne, and evaluate their potential as biomarkers and thus identify high-risk patients that may benefit from interventions, such as medications, pacemakers and defibrillators that prevent and treat arrhythmias.\n\n1.\tNollert G., Fischlein T., Bouterwek S., Böhmer C., Klinner W., Reichart B. Long-Term Survival in Patients With Repair of Tetralogy of Fallot: 36-Year Follow-Up of 490 Survivors of the First Year After Surgical Repair. 1997. JACC. Vol 30(5): 1374-1383.\n2.\tHarrison D., Harris L., Siu S., MacLoghlin C., Connelly M., Webb G., Downar E., McLaughlin P., Williams W. Sustained ventricular tachycardia in adult patients late after repair of tetralogy of Fallot. 1997. 30(5): 1368-1373.\n\n
REC name
North of Scotland Research Ethics Committee 1
REC reference
18/NS/0107
Date of REC Opinion
11 Apr 2019
REC opinion
Further Information Favourable Opinion