Early Prediction of Severe Sepsis (ExPRES-Sepsis) study (England)

• Research type

  Research Study

• Full title

  Early prediction of Severe Sepsis (ExPRES-Sepsis) study

• IRAS ID

  127421

• Contact name

  Timothy Walsh

• Contact email

  timothy.walsh@ed.ac.uk

• Sponsor organisation

  University of Edinburgh

• Research summary

  Between 6 and 16% of patients presenting to hospital emergency departments have infections, with half of these having signs of systemic inflammation (known as ‘sepsis’). A second issue is that, at time of presentation, it can be difficult to determine who has inflammation as a result of infection and who does not.
  Some of the patients with infections will deteriorate to organ failure (‘severe sepsis’) including failure of the heart and blood vessels to maintain normal blood pressure (‘septic shock’). Septic shock as arguably the most dangerous form of severe sepsis is associated with a significant mortality, which can be reduced by early intervention. However identifying those patients who are at high risk of deteriorating to septic shock can be difficult on initial presentation to hospital, and thus these patients risk being ‘triaged’ to an inappropriate level of care and/or missing the crucial early interventions which can modify mortality. Equally failure to identify which patients have underlying infections can lead to potential inappropriate targeting of antibiotics. Existing clinical and laboratory tests are often unable to accurately identify those patients with infection, and those who are likely to deteriorate to severe sepsis and septic shock.

  Our group has recently identified several signatures of immune system activation which predict those patients who are likely to deteriorate. Such tests would have major benefits for the management of patients with early suspected infection if they can be translated into a test usable in everyday clinical practice. This study aims to determine the prevalence of these markers in a cohort of patients admitted with suspected sepsis, and their predictive ability for developing established septic shock

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  13/SC/0266

• Date of REC Opinion

  29 Aug 2013

• REC opinion

  Further Information Favourable Opinion