Early Markers of Pancreas Transplant Acute Rejection (EMPAR) ver 1

• Research type

  Research Study

• Full title

  The role of donor derived cell free DNA (cfDNA), islet derived exosomes and proinsulin in diagnosing pancreas graft acute rejection.

• IRAS ID

  293665

• Contact name

  Argiris Asderakis

• Contact email

  argiris.asderakis@wales.nhs.uk

• Sponsor organisation

  Cardiff and Vale UHB

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  This project aims to identify potential markers for early pancreas graft rejection. Available current markers (amylase, lipase) have low sensitivity and specificity and as a result there is a number of undiagnosed cases of rejection. This project will involve recipients of pancreas transplantation and requires blood samples when rejection is suspected. The samples will be analysed using: donor origin cell free DNA, islet derived exosomes and proinsulin and the results will be correlated with pancreas transplant biopsies and biochemical results taken for clinical reasons.

• REC name

  London - Brighton & Sussex Research Ethics Committee

• REC reference

  23/PR/0258

• Date of REC Opinion

  20 Mar 2023

• REC opinion

  Further Information Favourable Opinion