e-nose assessment of VOC’s in colorectal cancer patients
Research type
Research Study
Full title
Characteristics of volatile organic substances (VOC’s) in the urine and stools of patients with colorectal cancer (CRC), their first degree relatives and individuals with whom they share dwellings
IRAS ID
127365
Contact name
Chuka Nwokolo
Contact email
Research summary
The enose is able to characterise volatile substances present in urine and stools of humans and in some cases detect perturbations associated with diseases including cancer. About 85% of colorectal cancer is sporadic there being no overt evidence of an inherited risk pattern. However like in most diseases it is likely that “nature“ and “nurture“ contribute to the disease process when it occurs sporadically. There is also some evidence that the environment including dietary factors may affect colorectal cancer risk. The enose detects a bioprofile of VOC’s in humans that is probably a summation of genetic and environmental factors affecting an individual. The aim of this study is to compare enose assessed profiiles of VOCs in the urine and stools of colorectal patients, their first degreee relatives (with who they share genes) and partners/spouses (with who they share their environment). We aim to assess the relative contribution of genetic and environmental factors to the risk of sporadic colorectal cancer.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
13/WM/0136
Date of REC Opinion
18 Jun 2013
REC opinion
Further Information Favourable Opinion