DynaSSaur
Research type
Research Study
Full title
DynaSSaur: Dynamic Chest X-ray with Simultaneous Spirometry
IRAS ID
322890
Contact name
David Green
Contact email
Sponsor organisation
Liverpool Heart and Chest Hospital
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Dynamic chest x-ray (DCR) is a novel radiographic technique that enables us to visualise the movement of the chest and lungs in real time by recording a series of x-ray images over 10-20 second interval. DCR provides an assessment of structures involved in respiration over time period and could therefore provide us with insights into respiratory function. It may be possible that relating DCR to conventional breathing tests allows it to be used as a surrogate tool to measure lung function. Alternatively, it may provide different parameters of lung function which don’t directly correlate with conventional testing, but are of themselves clinically relevant.
To evaluate the utility of DCR as a tool for assessment of baseline respiratory physiology, it is important to be able to compare it with real time conventional pulmonary function tests such as spirometry. Previous studies have compared sequential lung function testing to dynamic x-ray images; however, there may significant variability in 2 separate maneuvers as they are effort and technique dependent (i.e when performing a dynamic x-ray followed by spirometry or vice versa). Currently there have been no studies which compare a dynamic chest x-ray with a simultaneous lung function test such as spirometry.
This study will aim to address this issue by performing simultaneous spirometry and DCR to establish how DCR compares with spirometry in a healthy population of individuals. We would seek to also perform the DCR with simultaneous spirometry in a cohort of people with cystic fibrosis (pwCF), this would allow for comparison between the two groups. Furthermore the DCR has been part of our annual review process for pwCF since 2019. We therefore intend to review DCR metrics to see how changes over time relate to other key parameters of CF such as spirometry.REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
23/EM/0191
Date of REC Opinion
16 Aug 2023
REC opinion
Favourable Opinion