(duplicate) Novel CT markers of disease severity in diffuse lung disea
Research type
Research Study
Full title
Evaluation of Novel Computed Tomography(CT) Features of Disease Severity in Diffuse Lung Disease
IRAS ID
204290
Contact name
Anand Devaraj
Contact email
Sponsor organisation
Royal Brompton Hospital
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
In patients with diffuse lung diseases such as chronic obstructive pulmonary disease (COPD) and fibrotic interstitial lung disease (ILD), lung volumes may be increased or decreased respectively. Lung volume function testing is the most commonly used marker of lung volume alteration. In both ILD and COPD, CT markers of disease severity are limited to extent of fibrosis/ volume loss and visual/automated evaluation of emphysema respectively. However, there are limited studies to date that assess lung volumes directly.
In this project, we hypothesize that novel CT signs of lung volume alteration may provide additional diagnostic and prognostic information in patients with diffuse lung disease. We aim to establish CT anatomy of lung fissures and diaphragm in normal individuals. We will test the relationship between novel CT signs of lung volume alteration and lung function tests as well as the automated lung volume measurement on CT. We will test the value of novel CT signs including fissural/diaphragmatic displacement as markers of disease severity in patients with various diffuse lung diseases. We aim to work with Imperial college bioengineering department to develop a software analysing fissural position.
This retrospective study will be conducted at the Royal Brompton Hospital. 200 normal individuals will be identified by reviewing clinical and radiological databases looking for normal CT and pulmonary function test(PFT).Those who have had normal CT within 6 months of PFTs will be included in the study. If sufficient normal cohort cannot be collected from this centre alone (Royal Brompton Hospital), we aim to collect data from clinical and radiological databases at King's College Hospital. Patients with diffuse lung disease and COPD will be identified from the existing clinical and histopathological databases. The study will last 1 year and will be funded by the Royal Brompton and Harefield NHS Foundation trust.
REC name
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REC reference
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