(duplicate) Non-invasive cardiac output measurement in the Emergency Department
Research type
Research Study
Full title
An observational study to define the ability to assess non–invasive measurement of cardiac output and preload in a convenience sample of patients in the Emergency Department.
IRAS ID
172012
Contact name
Tim Harris
Contact email
Duration of Study in the UK
0 years, 5 months, 0 days
Research summary
The study will define the ability of non-invasive methods to estimate the fluid status of patients presenting to the emergency department. These patients may have acute circulatory failure that requires rapid correction of fluid status. Patients may be:
1. fluid overloaded due to heart failure and require diuretics to offload intravascular fluid;
2. fluid depleted due to sepsis or dehydration and require intravenous fluid resuscitation.Current techniques to assess fluid status are either unreliable, such as clinical examination, or invasive and inappropriate for many patients.
Previous studies have showed that non-invasive techniques such as ultrasound, bioreactance and non-invasive pulse contour analysis can be useful to estimate fluid loss by dehydration or bleeding.
Ultrasound techniques can be used to measure the changing diameter of a large abdominal vessel, the inferior vena cava or the volume of blood which passes through arteries such as the aorta or the carotid. Ultrasound can also measure the volume of blood the heart pumps out per contraction. Bioreactance can measure cardiac output by detecting the changing volume of blood in large thoracic arteries with each heart beat. Pulse contour analysis assesses the change in blood pressure in the wrist and finger and calculates the corresponding volume of blood pumped out of the heart. Our study aims to see if these tools to measure cardiac output can be used in the emergency department setting and which operates most effectively in that setting.
The findings may be used to inform a randomised trial of goal directed fluid therapy.
REC name
East of England - Essex Research Ethics Committee
REC reference
15/EE/0227
Date of REC Opinion
17 Jul 2015
REC opinion
Further Information Favourable Opinion