Drug resistant TB contacts registry
Research type
Research Study
Full title
Drug resistant TB contacts registry. A register of multi-drug resistant TB contacts. V4
IRAS ID
214570
Contact name
Katherine Gaskell
Contact email
Sponsor organisation
London School of Hygiene and Tropical Medicine
Duration of Study in the UK
2 years, 5 months, 0 days
Research summary
Multi-drug resistant tuberculosis (MDR TB) is an ongoing threat to UK and global public health which the World Health Organisation (WHO) aims to control. TB contact tracing is one part of controlling disease spread. This is currently not done systematically with information technology systems nor is it known how many MDR TB contacts there are in total. The WHO and Public Health England (PHE) are currently unable to give guidance on how to manage these patients as there is a complete lack of data. This study aims to recruit MDR TB contacts into an observational cohort on a registry with a nested mixed methods study to test the usability of a mobile application (app) that improves existing MDR TB contact tracing services within the National Health Service (NHS). TB nurses will use the app to systematically enter data onto a registry on a secure server. Nurses will receive a secure data summary via NHS email, enabling monitoring of patients and reducing administrative burden. The cohort will follow 80 consecutive contacts of MDR TB patients from presentation with 6 monthly appointments for 2 years from enrolment. The app will enable nursing adherence to Public Health England (PHE) guidance, it does not change participant clinical care or management.
The research questions are: What are the outcomes of MDR TB close contacts 2 years after exposure to an infectious case? And can we use a mobile app to record these outcomes in a registry of contacts?
Total numbers of contacts on the registry will be compared with contact numbers in patient notes. End user experience will be captured with structured nurse interviews. Anonymous stakeholder questionnaires will assess patient acceptability of a registry. Initially this study will be piloted at one TB clinic, we foresee expansion to further TB clinics across London.
REC name
London - London Bridge Research Ethics Committee
REC reference
16/LO/2032
Date of REC Opinion
3 Jan 2017
REC opinion
Further Information Favourable Opinion