Drug Lung Deposition In COPD

• Research type

  Research Study

• Full title

  Improving Inhaler Treatment and Small Airways Assessment in Chronic Obstructive Pulmonary Disease

• IRAS ID

  88168

• Contact name

  Omar Usmani

• Contact email

  o.usmani@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Eudract number

  2011-005544-10

• ISRCTN Number

  not known

• Research summary

  Chronic obstructive pulmonary disease (COPD) patients experience breathing difficulties because the deep airways in their lungs become narrowed. COPD patients use inhaler drugs to provide relief. However, current inhalers are inefficient. They deliver a ‘coarse-mist’ of drug-droplets that do not reach the deep airways.

  In our study, we will use a ‘fine-mist’ inhaler of drug-droplets, tagged with radioactive tracer to track them. We will take lung images to see if the drug-droplets reach the deep airways, and determine if this improves breathing in patients. Our research may allow development of new, more efficient inhalers to improve treatment for COPD patients.

• REC name

  London - West London & GTAC Research Ethics Committee

• REC reference

  12/LO/0004

• Date of REC Opinion

  19 Jan 2012

• REC opinion

  Further Information Favourable Opinion