Does Bone Health Index Correlate with HRpQCT in children?
Research type
Research Study
Full title
Does Bone Health Index (BHI) correlate with High-Resolution Peripheral Quantitative Computed Tomography (HRpQCT) parameters including finite elements analysis (FEA) in children?
IRAS ID
282708
Contact name
Amaka C Offiah
Contact email
Sponsor organisation
Sheffield Childrens NHS Foundation Trust
Duration of Study in the UK
3 years, 11 months, 30 days
Research summary
The main purpose of this study is to measure bone strength and density in children and young adults by using two novel imaging techniques: digital X-ray radiogrammetry (DXR) and high-resolution peripheral quantitative computed tomography (HR-pQCT)], and to determine the degree of correlation between these imaging modalities
Digital X-ray radiogrammetry (DXR): It is a quick and painless bone imaging method used to measure bone density and bone age from your child’s hand radiograph using special computer software called the BoneXpert system. This software was developed specifically for measuring bone age and bone mass in children by calculating the dimensions of three middle finger bones from hand radiographs, and results are expressed as a specific value called the bone health index (BHI).
High-resolution peripheral quantitative computed tomography (HR-pQCT):It is a novel imaging method used to scan the very ends of long bones and gives images similar to looking at bone samples under the microscope. The HR-pQCT measurements are able to provide a more precise indication of bone strength than other techniques available, including dual-energy x-ray absorptiometry (DXA).
This study is a prospective observational cohort study. Over a 2-year period, we will recruit twenty healthy children and twenty bisphosphonate naïve patients (with reduced bone mineral density, as confirmed by DXA) aged between 8 and 14 years. Healthy participants will be recruited by approaching healthy siblings of patients and via generic email to staff of Sheffield Children’s Hospital (SCH) and the University of Sheffield. while patients will be recruited from Sheffield Children’s Hospital (SCH), according to our inclusion criteria.
The results of this study will potentially benefit children and their families who can have early and reliable diagnoses made and receive treatment to improve their quality of life or even prevent them from having low trauma fractures altogether.REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
21/EE/0056
Date of REC Opinion
16 Mar 2021
REC opinion
Favourable Opinion