Diversion Colitis
Research type
Research Study
Full title
An investigation into the effects of faecal diversion on colonocyte substrate utilisation
IRAS ID
188621
Contact name
Lavinia Onos
Contact email
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Surgery in the abdomen which involves creating a stoma (bringing a small loop of bowel onto the surface of the abdomen) causes a temporary disruption in gut function. Studies have shown that this disruption of gut function can cause inflammation of the colon after surgery. This is known as 'diversion colitis'.We would like to find out more about diversion colitis and how it affects the bowel.
In order for cells in the large bowel (colon) to function they need their own food or energy source. We think that these cells in the colon (known as colonocytes) prefer to get their food from a group of substances called fatty acids which are formed in the small bowel. When somebody has a stoma (a loop of the small bowel is brought to the surface of the abdomen) those fatty acids no longer get to the large bowel as they come out of the stoma. We think that diversion colitis may be caused by a shortage of these fatty acids.
We would like to investigate this further by analysing tissue taken from the large bowel when people have their initial surgery and again when they have their second operation (when closure of the stoma is considered). Both samples will be taken while patients are asleep under general anaesthesia. The samples will be taken for specialised laboratory analysis at the Univesity of Hull.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
15/YH/0412
Date of REC Opinion
9 Nov 2015
REC opinion
Further Information Favourable Opinion