Dietric/Version 1.0
Research type
Research Study
Full title
Bariatric Surgery: The Role of Intestinal Versus Gastric Mechanisms in the Regulation of Dietary Intake, Body Weight and Metabolism.
IRAS ID
255980
Contact name
Francesco Rubino
Contact email
Sponsor organisation
King's College London, King's College Hospital co-sponsored
Duration of Study in the UK
2 years, 7 months, 10 days
Research summary
The proposed study aims to investigate the impact of weight loss surgeries on dietary intake, quality of life, body composition and metabolism. Two specific types of bariatric surgeries will be included, they are Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). These types of surgeries were chosen because of their district involvement in parts of the gastrointestinal tract (gastric vs intestinal). Thus, understanding the physiologic mechanism of different parts of the gastrointestinal tract in humans. The dietary data will include micronutrient intake, macronutrient intake, meal pattern and dietary behaviours. Body composition measurements will consist of weight, height, waist circumference, waist to hip ratio and body fat percentage. The metabolism will be tested by measuring the resting energy expenditure and appetite/hunger-related gastrointestinal hormones. \nThe study will be testing dietary intake, body composition and metabolism before surgery and at both early (1-3 month) and long-term (3-5 years) after surgery. Patients will be recruited from the bariatric clinic at King’s College Hospital. Participants will be asked to write a 3-day food diary, complete a dietary behaviours questionnaire and a quality of life questionnaire, and have their body composition measured. A subset of the study sample (~15 per each type of surgery) will provide venous blood samples that will be used to measure gastrointestinal hormones and have their body’s resting energy expenditure estimated by Indirect calorimetry. In addition, the study will recruit participants of normal weight to be compared with patients of weight loss surgeries.\nThe further understanding of the differences in the physiologic mechanisms of RYGB and SG can help in the future development of new treatments for obesity and obesity-related comorbidity. These findings will inform the improvement of nutritional health and help in the clinical management of surgical patients to predict the short and long-term outcomes of weight loss surgeries.[COVID-19 amendment 09/04/2020] To allow for patients in the cross-sectional study to be recruited after 15 months from surgery instead of after >=3 to 5years from surgey\n2) add the information sheet when we post the appointment reminder for the clinic) put an advertisement in the clinic waiting room, corridors and reception to increase potential participants awareness of the study) send the questionnaires and food diary by post/mail to the participants who have agreed to receive this invitation) Skip a minimum of 24 hours to read the study information sheet and decide if they want to participate and consent, only for the participants who want to complete only the questionnaires and food diary.
REC name
London - Surrey Research Ethics Committee
REC reference
19/LO/0731
Date of REC Opinion
10 Jun 2019
REC opinion
Further Information Favourable Opinion