Diastolic Ventricular Interaction in patients with HFnEF
Research type
Research Study
Full title
Diastolic Ventricular Interaction in patients with Heart Failure with Normal Ejection Fraction
IRAS ID
128381
Contact name
Michael P. Frenneaux
Contact email
Sponsor organisation
University of East Anglia
Clinicaltrials.gov Identifier
Research summary
Some people with symptoms of heart failure have a normal or near normal pumping function of the heart. The main problem in these people appears to be that the heart is abnormally stiff during exercise, therefore preventing it from filling properly. As a result, the pressure in the left side of the heart increases and this is transmitted to the lungs and the right side of the heart.
We suspect that this increased pressure in the right side of the heart, squashes the left side, reducing the filling of the left side of the heart and leading to a vicious cycle.
We also believe that the squashing of the left side of the heart by the right side, changes the shape of the left ventricle, which can lead to a leaky valve on the left side which will make the symptoms even worse.
The purpose of this study is to understand the basis for the failure of the heart to increase its output of blood to meet the demands of exercise.
REC name
North of Scotland Research Ethics Committee 1
REC reference
13/NS/0044
Date of REC Opinion
11 Jul 2013
REC opinion
Further Information Favourable Opinion