Diastolic function assessment with cardiac magnetic resonance imaging
Research type
Research Study
Full title
Diastolic function assessment with cardiac magnetic resonance imaging and echocardiography: a scan-rescan study
IRAS ID
297292
Contact name
James Howard
Contact email
Sponsor organisation
Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Cardiac magnetic resonance (CMR) imaging is excellent at assessing the contractility of the heart muscle. However, relatively little is known about CMR’s ability to assess the relaxation (diastolic function) of the heart between heart beats, where echocardiography remains the gold standard. This is important because in 30% of heart failure patients the overwhelming problem is diastolic dysfunction, and so they often need both tests.
Studies have previously tried to compare CMR measurements of diastolic function those from echocardiography, but these have shown frequent disagreements between the two in the same patient. The reasons for this are not known. Possible explanations include differences in the way the scanners take pictures, differences in how the patient is positioned, and the reproducibility of each method.
In this study we will recruit patients who are undergoing a CMR scan for clinical reasons. Before their scan we will perform an echocardiogram to assess diastolic function, with the patient lying in different positions. Then, during their CMR scan they will undergo diastolic function assessment twice, around 30 minutes apart. After the CMR scan we will repeat the echocardiogram. Finally, when patients come back to the hospital for their clinical follow-up some weeks later we will perform repeat CMR and echo scans.
These assessments in each patient on the same day and different days will allow us to assess the agreement between CMR and echocardiography diastolic assessment, which is imperative if we wish to develop guidance for doctors to better assess our patients.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
22/EE/0042
Date of REC Opinion
13 Apr 2022
REC opinion
Further Information Favourable Opinion