Development of hybrid scaffolds for kidney tissue engineering
Research type
Research Study
Full title
Development of hybrid 3D scaffolds for kidney tissue engineering by combination of human decellularized extracellular matrix and polymer
IRAS ID
294292
Contact name
Busra Baskapan
Contact email
Sponsor organisation
Institute for Bioengineering
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
According to Kidney Care UK 3 million people in the UK has chronic kidney diseases at an advanced level. Only treatment option for end stage renal failure is transplantation, however donor kidneys meets only one fifth of demand. This shortage causes so long waiting time for patients that every day one will die while waiting transplant. Besides, 12% of donor kidneys is deemed unsuitable for transplantation in the UK.
Since the paucity of current treatment options for renal failure reveals a need for more reliable and effective methods for kidney diseases we aim in this project to turn this source of discarded donor kidneys into biofunctional hybrid scaffolds that could be implantable. Use of decellularized human kidney deemed unsuitable for transplant would be a promising technique to recycle excess transplant.
This project proposes to fabricate a hybrid scaffold from decelled human kidney extracellular matrix (ECM) and synthetic polymer. ECM hosts many essential proteins that maintain homeostasis via biochemical signals within the tissue. Synthetic polymers enable to obtain cost-effective and modifiable porous scaffold. Combining these materials eliminate the disadvantages of each material such as poor mechanical properties of ECM and lack of bioactivity of polymer.
Hybrid sacffolds will be built and renal cells behaviour on these scaffolds under different conditions will be examined. The project also aims to compare the human kidney study with our ongoing rat ECM combined with polymer so we could see the species differences.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
21/EE/0049
Date of REC Opinion
12 Apr 2021
REC opinion
Further Information Favourable Opinion