Development and function of human immune cells
Research type
Research Study
Full title
Development and function of human immune cells
IRAS ID
200839
Contact name
Francesco Colucci
Contact email
Sponsor organisation
Cambridge University Hospital NHS Trust and University of Cambridge
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
The purpose of this study is to investigate the development of human immune cells. We have a special interest in Natural Killer (NK) cells in reproduction and cancer. Development of NK cells is only partially understood and a better knowledge of how NK cells develop from progenitor cells, how they relate to other lineages and how they function may improve our understanding of NK function in health and disease. The biology of NK cells is regulated by variable receptors (known as KIR), which are typically determined by DNA genotyping. Human tonsils are the most suitable and accessible tissue rich in progenitors of NK cells.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
16/WM/0283
Date of REC Opinion
5 Aug 2016
REC opinion
Further Information Favourable Opinion