Determining the Pathogenesis of Proliferative Vitreoretinopathy
Research type
Research Study
Full title
Determining the pathogenesis of proliferative vitreoretinopathy (PVR) formation through the analysis of protein and RNA levels expression in patients with retinal detachments
IRAS ID
288361
Contact name
Manjit Mehat
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
N/A, N/A; ,
Research summary
This study aims to better understand a major cause of visual loss in the UK; Proliferative Vitreoretinopathy (PVR).
A light-sensing film at the back of the eye is called the retina. The centre of the eye is filled with a jelly-like substance called the vitreous. The vitreous is attached to the retina. However, as we age the vitreous liquefies and separates from the retina. As the vitreous pulls away from the retina it may create a tear. These tears or breaks in the retina allow the liquefied fluid to gather underneath the retina and detach it. This accumulation of fluid and separation of the retina is called a retinal detachment. Retinal detachment requires prompt keyhole surgery at the back of the eye to re-attach the retina and prevent the loss of vision.
If there is a delay in surgery, inflammation occurs, causing scarring on the retina. This is known as proliferative vitreoretinopathy (PVR). The presence of PVR increases the risk of surgical failure, vision loss and the need for multiple operations.
This study aims to better understand how the processes with which PVR develops in the eye following a retinal detachment. To do so, we will take samples of the vitreous and PVR scar tissue that would normally be removed and discarded as part of your keyhole surgery for the repair of your retinal detachment. Instead of discharging these samples, we would collect them for analysis, in an attempt to identify ways in which we can prevent this devastating cause of visual loss. Patients will be invited to join the study when they are listed for retinal detachment surgery.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
23/LO/0311
Date of REC Opinion
20 Mar 2023
REC opinion
Further Information Favourable Opinion