Detection of Hepatorenal Syndrome by Magnetic Resonance Elastography
Research type
Research Study
Full title
Detection of Hepatorenal Syndrome in Cirrhotic Patients by Magnetic Resonance Elastography (MRE)
IRAS ID
123190
Contact name
David J Lomas
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Research summary
This is a feasibility/pilot study designed to investigate the diagnostic accuracy of magnetic resonance elastography (MRE) for the detection of hepatorenal syndrome in patients with underlying cirrhosis. Hepatorenal syndrome (HRS) is a severe form of renal failure that develops in cirrhotic patients as a result of a persistent decline in the renal blood flow. Due to absence of specific diagnostic biomarkers, the HRS diagnostic criteria is at present based exclusively on a set of defined clinical and biochemical parameters. The investigators plan to study if MRE can be used as an imaging test for detecting HRS. This has potential clinical benefits including a more accurate and confident diagnosis, simplification and shortening of the diagnostic process and more expedient patient management. In this proposed 15-month long study, an MRE examination will be performed on eligible hepatology inpatients with cirrhosis at Addenbrooke’s Hospital. The findings on MRE will be correlated with the associated clinical and biochemical data in each case.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
13/EE/0152
Date of REC Opinion
10 Jul 2013
REC opinion
Further Information Favourable Opinion