Delayed post-exertional malaise in chronic fatigue syndrome

• Research type

  Research Study

• Full title

  Chronic Fatigue syndrome (CFS) and the value of monitored exercise testing in diagnosis and explantation of post-exertional malaise.

• IRAS ID

  112354

• Contact name

  Dilip Shah

• Contact email

  dilip.shah@etsh.nhs.uk

• Sponsor organisation

  Espom St Helier Univesity Hospital

• Research summary

  Patients with Chronic fatigue syndrome (CFS) have delayed malaise following any physical, mental or emotional exertion. This is known as Post exrertional malaise (PEM). We intend to assess the peak oxygen consumption and anaerobic threshold (gold standards for exercise capacity), memory function and parameters of immune activation 30-60 minutes after exercise and 24 hours later after similar submaximal exercise in patients with CFS and healthy controls. Comparison of the various parameters at baseline and 34 hours later may formally document the frequency and severity of PEM affecting both physical mental function and shed some light on the affect of this factor on immune and activation and dysfunction. It is possible that assessing PEM after exercise testing may provide an objective diagnostic test to clarify the diagnosis of CFS.

• REC name

  London - Stanmore Research Ethics Committee

• REC reference

  13/LO/0266

• Date of REC Opinion

  23 May 2013

• REC opinion

  Further Information Favourable Opinion