Dejour Test validity study & its use in respiratory failure.
Research type
Research Study
Full title
Validity study for the Dejour Test, a non-invasive way of measuring oxygen sensitivity from an exhaled breath test, & its use in chronic respiratory failure.
IRAS ID
133956
Contact name
Alice Turner
Contact email
Sponsor organisation
Heart of England NHS Foundation Trust
Research summary
We do not yet know which group of patients with chronic respiratory disease will deteriorate, develop type II respiratory failure (inability of the lungs to maintain oxygen levels and excrete carbon dioxide effectively) and consequently oxygen sensitivity. Current practice relies on monitoring by capillary blood gas measurements and spirometry. Thus a test that would discriminate between those at risk of type II respiratory failure and sensitivity to oxygen therapy could potentially obviate the need for continued invasive monitoring. Prescription of long term oxygen therapy (LTOT) could also then be based on saturations alone in those not at risk of developing type II respiratory failure. The Dejour Test is a non-invasive, rapidly performed single breath test which could be used to separate out those that are at risk of type II respiratory failure. This will be an observational case-controlled study. 30 patients with established respiratory failure attending an outpatient oxygen clinic will be recruited, along with 30 age matched controls. Since we do not yet know the variability of this test in the population it is impossible to be confident of power and it is possible that numbers will need to be increased dependent on initial results. Patients with established respiratory failure will be recruited from the Oxygen Assessment Clinic. Healthy controls would be recruited from adverts within the hospital and from local resources such as the University of Birmingham Healthy Elders database. This will ensure that the full age range is represented, in case this affects the performance of the test. Spirometry, the dejour test and capillary blood tests will be performed on each study participant. The reliability and validity of the dejour test will then be assessed by calculating the sensitivity, specificity, negative and positive predictive values.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
13/WM/0467
Date of REC Opinion
9 Jan 2014
REC opinion
Further Information Favourable Opinion