DECODE III Study
Research type
Research Study
Full title
DNA Damage & Repair in Patients with ST-Elevation Myocardial Infarction
IRAS ID
320542
Contact name
Michael Mahmoudi
Contact email
Sponsor organisation
University Hospital Southampton NHS FT
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
The progressive deposition of cholesterol along the wall of one or more of the three main arteries (commonly referred to as coronary artery) that supply the heart muscle leads to the formation of fatty deposits called coronary atheroma. These fatty deposits can damage the wall of such arteries and cause a small tear allowing blood to come into contact with cholesterol crystals, form blood clots, causing the artery to block. When this happens, blood can no longer reach the heart muscle and heart muscle death begins to occur. This condition is called a heart attack and requires emergency treatment to unblock the affected artery and restore blood flow thus minimising further heart muscle damage.
There is increasing evidence to suggest that genes and proteins that are responsible for signalling DNA damage and DNA repair may be implicated in the molecular pathways that lead to the development of coronary atheroma. We have preliminary data that indicates patients who develop coronary atheroma may have reduced DNA repair activity in their circulating blood cells called peripheral blood mononuclear cells. The aim of this study is to determine if such genes and proteins play a role in patients presenting with a heart attack.REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
23/LO/0070
Date of REC Opinion
27 Jul 2023
REC opinion
Further Information Favourable Opinion