Decellularisation of tissues for use as scaffolds in tissue repair.
Research type
Research Study
Full title
Characterisation of the process of decellularisation of human tissues for use as scaffolds for autologous cells in tissue repair.
IRAS ID
148128
Contact name
Gillian McNally
Contact email
Sponsor organisation
Tissue Regenix
Duration of Study in the UK
5 years, months, days
Research summary
This ethics application is to allow Tissue Regenix to prove their ability to decellularise human heart valve tissue and compare the functional, biochemical and biomechanical properties of decellularised human pulmonary heart valves (PHV) and aortic heart valves (AHV) with unprocessed PHV and AHV. These products are being developed to produce a better allograft, which not only retains its original features but also has a lower risk of host rejection since the donor antigens have been removed. The biological properties of the scaffold are therefore extremely important and it is crucial to show that the biological characteristics of the tissue are not fundamentally altered following the dCELL® process.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
14/YH/0108
Date of REC Opinion
24 Mar 2014
REC opinion
Favourable Opinion