DATA TDM
Research type
Research Study
Full title
Analysis of Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment to Assess the Potential Role of Therapeutic Drug Monitoring in UK Infection Management (DATA TDM study)
IRAS ID
306987
Contact name
Alison Holmes
Contact email
Sponsor organisation
Imperial College London
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
To address the challenge of antimicrobial resistance (AMR), it is imperative that the current finite pool of antimicrobial agents is optimised, to maximise therapeutic success, limit the risk of drug toxicity, whilst minimising emergence of resistance.
Outside the critical care setting, it is not known how many patients are receiving optimal drug concentrations for the treatment of infection. This study aims to assess whether antimicrobial targets are being achieved in these individuals, and explore how clinical co-variates and outcomes might relate to this. Furthermore, it aims to identify priority groups and/or drugs where there are gaps in dose-optimisation research, and develop hypotheses which can be tested in interventional studies.
Eligible participants will be enrolled and observed during their management for infection at Imperial College Hospital NHS Trust (ICHNT). After providing informed written consent, their clinical data will be collected from electronic healthcare records, and they will provide samples which will undergo drug concentration analysis.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
22/LO/0063
Date of REC Opinion
16 May 2022
REC opinion
Further Information Favourable Opinion