CYTOKINES & TIMED RELEASE TABLET PREDNISONE IN POLYMYALGIA RHEUMATICA

• Research type

  Research Study

• Full title

  CIRCADIAN VARIATIONS IN CYTOKINES AND THE EFFECT OF TIMED RELEASE TABLET PREDNISONE IN POLYMYALGIA RHEUMATICA

• IRAS ID

  10316

• Contact name

  John R Kirwan

• Sponsor organisation

  University Hospitals Bristol, NHS Foundation Trust

• Eudract number

  2008-007315-32

• Clinicaltrials.gov Identifier

  NCT00836810

• Research summary

  The study will show if overnight variations in blood levels of chemical messengers (called cytokines) which cause or reduce inflammation in polymyalgia rheumatica, are changed by taking a new timed release tablet that provides a dose of the glucocorticoid (steroid) prednisone at 2am. It will also find out if blood cytokines levels are related to the hormones of the hypothalamic-pituitary-adrenal (HPA) axis, which is the body's natural system for producing and controlling glucocorticoid productions.

• REC name

  South West - Cornwall & Plymouth Research Ethics Committee

• REC reference

  08/H0206/75

• Date of REC Opinion

  21 Jan 2009

• REC opinion

  Further Information Favourable Opinion