Cytokine exercise - surgery
Research type
Research Study
Full title
Pilot study to examine changes in cytokine and chemokine expression following maximal exercise and minimally invasive colorectal surgery
IRAS ID
326963
Contact name
Simon Davies
Contact email
Sponsor organisation
University of York
Duration of Study in the UK
1 years, 0 months, 6 days
Research summary
The purpose of this study is to look at the different measures of inflammation that we can measure blood, and to see how they change following exercise and surgery. These are called cytokines and chemokines. We are performing this study for two reasons, firstly we use exercise to try to decide what a persons risk might be having major surgery, and whilst this is a good test we don’t completely understand why it predicts risk. We know that surgery causes inflammation, and also that exercise causes inflammation as well. We think it may be possible that the amount of inflammation that exercise causes may be related to how fit you are, and also to how much inflammation you may get after surgery but we don't know. This study will help us find out this answer, and will help guide our future research to find out which blood tests, or combination, may be useful in helping to predict risk better. The other reason that we are performing this study is too look at the how different types of surgery may affect inflammation. Surgery on the bowel is often performed by keyhole surgery which we know causes less stress and inflammation than conventional surgery. An increasing amount of surgery is being performed assisted by a robot, as it is thought that people get home quicker. It is unknown if robotic surgery causes less inflammation than standard keyhole surgery, and if this is the reason that people get home faster.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
23/PR/1455
Date of REC Opinion
8 Dec 2023
REC opinion
Favourable Opinion