CVR Lacunar Stroke Study v1.0
Research type
Research Study
Full title
Non-invasive measurement of cerebrovascular reactivity and compliance in cerebral small vessel disease: CVR Lacunar stroke study
IRAS ID
116571
Contact name
Joanna Wardlaw
Contact email
Sponsor organisation
University of Edinburgh
Research summary
Cerebral small vessel disease is the commonest vascular cause of dementia, causes a fifth of strokes and physical disability in older people. The cause is unknown. Failing blood-brain barrier function, cerebral arteriolar wall thickening and impaired vasoreactivity are seen experimentally or pathologically. In vivo imaging shows blood-brain barrier malfunction and can measure cerebral microvascular reactivity, which is an important potential therapeutic target in small vessel disease. This project will test new magnetic resonance imaging methods to measure regional cerebral vasoreactivity and compliance in patients with small vessel stroke to determine if these methods are sensitive and practical enough to use as intermediary outcomes in early phase clinical trials of interventions to prevent progressive small vessel disease. Lack of patient data mean that this development is required to compare cerebral, retinal and peripheral vasoreactivity, provide proof of principle and determine sample size prior to phase 2 trials and mechanistic studies.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
14/EM/1126
Date of REC Opinion
13 Aug 2014
REC opinion
Favourable Opinion