CT coronary angiography for Type 2 Myocardial Infarction
Research type
Research Study
Full title
A pilot clinical trial of CT coronary angiography in patients with suspected Type 2 myocardial infarction
IRAS ID
321651
Contact name
Richard I S Good
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Clinicaltrials.gov Identifier
RE/18/6134217, BHF Centre of Research Excellence Grant Reference
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
An increasing number of patients present to hospital with a heart attack (myocardial infarction, MI). Heart attacks can be caused by instability and narrowing in heart arteries (Type 1 MI) or strain on the heart (Type 2 MI). Type 2 MIs can be the result of other problems with the heart including inflammation and rhythm problems or other conditions such as infection or low blood count. Both Type 1 and Type 2 MI patients have increased risk of further problems following this presentation. Deciding whether a patient has suffered a Type 1 MI or a Type 2 MI can be very difficult leaving uncertainty for patients and health care staff.
Often patients with Type 2 myocardial infarction are either referred for an invasive coronary angiogram (a procedure where we inject dye into the heart arteries directly) or have no further investigations. Invasive angiograms carry a small risk of complications including heart attack, stroke and, rarely, death.
Cardiac CT scanning has emerged in the last 20 years as the first test we usually perform to investigate patients that present with stable chest pain symptoms to the outpatient department. The role of cardiac CT in patients that present as an emergency with a suspected heart attack is not yet established.
This study is to explore whether a CT scan of the heart arteries might improve the care of patients that have presented with a suspected Type 2 MI. We hope to demonstrate that these patients may be the ideal group of patients to benefit from cardiac CT scan imaging by; 1. confirming whether they have any disease in their heart arteries 2. demonstrating the severity of the heart artery disease 3. revealing an alternative cause for their presentation 4. avoiding the need for an invasive heart artery angiogram.REC name
West of Scotland REC 5
REC reference
23/WS/0053
Date of REC Opinion
27 Apr 2023
REC opinion
Further Information Favourable Opinion