CT and 3D airway modeling to estimate mucociliary clearance in COPD
Research type
Research Study
Full title
Estimating Mucociliary Clearance delivered by High Frequency Chest Wall Oscillation to patients with COPD and mucus hypersecretion or frequent exacerbations, using CT scan and 3D modeling of airway caliber
IRAS ID
94124
Contact name
Indranil Chakravorty
Contact email
Sponsor organisation
Electromed Inc USA
Research summary
Mucociliary clearance (MCC) is an important mechanism for removing inhaled particles, secretions and cellular debris from the respiratory tract. MCC is known to be impaired in patients with COPD, impairing host defense leading to the retention of inhaled foreign particles, contributing to frequent admission to hospital.
The primary aim of the study is to estimate the efficiency of mucociliary clearance based on measurement of airway calibre using CT scan and 3-dimensional airway modeling (airway thickness Pi10 and airway wall lumen percent).
The secondary aim is to determine if the use of a High Frequency Chest Wall Oscillation (HFCWO) device improves health related quality of life and dynamic of small airway function (Forced Expiratory Flow at 25-50% volume FEF 25-75).
Patients with COPD and mucus hypersecretion/ bronchiectasis over the age of 40 (to reduce the overlap with asthma) with a >10 pack year history of smoking, will be recruited into the study. The patients will use the vest for two sessions per day. All patients will have a baseline high resolution CT scan (HRCT) and a follow up scan following a 2 weeks intervention. The scans will then be analyzed using an established algorithm to determine if there has been any change in airway calibre, improvement in QoL and small airway function.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
13/EE/0076
Date of REC Opinion
22 May 2013
REC opinion
Further Information Favourable Opinion