Crown
Research type
Research Study
Full title
Evaluation of the haemodynamic performance of Crown PRT aortic valve bioprosthesis
IRAS ID
219752
Contact name
Hope Howard
Contact email
Sponsor organisation
University Hospital Southampton
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Aortic valve replacement is the treatment of choice for patients with narrowing of the aortic valve; a major heart valve. Valves made from animal’s tissues are widely used. These do not require blood thinning medications (warfarin).
Different types are present in the market with different designs. The decision to use one or other is up to the surgeons. The choice is based on the anatomy of the patient, data on longevity of the valve, ease for implantation and best outcome for the patient.
We have recently looked at our preliminary experience with one type of valve called the Crown PRT valve. The Crown PRT valve is a new stent bovine bioprosthesis that received the CE mark in July 2014. The valve design consists of a single bovine pericardium layer that underwent an advanced tissue treatment – the phospholipid reduction treatment (PRT) – which is intended to reduce the valve calcification thus to improve the durability of the prosthesis. We recently reported our experience of this valve. No adverse device effects were recorded and pre-discharge ultrasound assessment showed no valvavular leakage and normal postoperative pressures.
This study will enable us to extend the observation of ultrasound assessment and clinical status in participants up to 1-year of follow-up.
REC name
London - Central Research Ethics Committee
REC reference
17/LO/1004
Date of REC Opinion
13 Jul 2017
REC opinion
Further Information Favourable Opinion