CPET MPP Study
Research type
Research Study
Full title
Assessing the Effect of Multipoint Pacing (MPP™) in Cardiac Resynchronization Therapy with AV node block on QRS duration and Exercise Capacity
IRAS ID
330216
Contact name
Neil Herring
Contact email
Sponsor organisation
Address University of Oxford Research Governance, Ethics & Assurance
Duration of Study in the UK
2 years, 0 months, 30 days
Research summary
In patients with heart failure, uncoordinated contraction of the chambers can be corrected using a cardiac resynchronization therapy (CRT) pacemaker. These devices make patients live longer by improving how the heart pumps and reduce patients symptoms. Unfortunately not all patients respond to CRT, however bespoke programming of the device can greatly improve success.
CRT coordinates heart contraction by pacing the different chambers of your heart via the wires, or leads, which were placed into the heart when it was implanted. This pacing is coordinated by special software, or algorithms, in the device. A new algorithm allows the pacemkaer to pace the left ventricle (the main pumping chamber of the heart) from two separate points called Multipoint Pacing (MPP). This may be more efficient than the traditional way of pacing the heart and could help the heart function improve even more. This algorithm is able to deliver two separate electrical impulses to your left ventricle per heart cycle, which provides greater options to personalize pacemaker settings to individual patients, and capture more of the heart than with traditional pacing algorithms.
What is not clear is how effective multipoint pacing is during exercise. We plan to investigate this by monitoring the ECG whilst accurately measuring exercise performance during a cardiopulmonary exercise test (CPET) on an exercise bike. We will ask participants to rate their perceived exercise intensity to see whether fusion pacing improves ECG resynchronization, exercise performance, and patients' symptoms compared to standard programming. Twenty-two participants with CRTs will each undergo two CPET tests 2 weeks apart, with programming randomised and blinded on both occasions to MPP and standard programming.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
23/SC/0380
Date of REC Opinion
5 Dec 2023
REC opinion
Further Information Favourable Opinion