COVIP: COVID-19 in very old intensive care patients [COVID-19]
Research type
Research Study
Full title
Clinical course and prognostic factors of COVID-19 infection in very old intensive care patients - A study being undertaken in the UK as part of a multicentre, multinational, observational study of the same name.
IRAS ID
283388
Contact name
Susannah Leaver
Contact email
Sponsor organisation
St George's University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 2 months, 30 days
Research summary
Preliminary data show that very old patients with multimorbidity have a high risk of dying from a severe infection with the severe acute respiratory syndrome caused by corona virus 2 (SARS-CoV-2). However, it is unclear whether chronological age is in itself an independent risk factor, or whether the burden of comorbid diseases and age-related syndromes, especially frailty, play a major role. Previous studies by the VIP international research group have found that such co-factors are often more important than chronological age itself in patients not infected with COVID-19, who have been admitted to intensive care.\n\nThe COVIP study group proposes to investigate the relationship between age, co-morbidities, pre-treatment, frailty, and outcomes in a group of elderly patients receiving critical care for COVID-19. It will explicitly investigate how the frailty and nursing situation was before the acute illness, which comorbidities existed and how the therapy was carried out in the intensive care unit.\n\nThe results of this novel investigation will be of great importance to understand the most important factors that can predict mortality in elderly COVID-19 patients. In addition, the proposed study will provide a solid knowledge base necessary to guide triage decisions in the future. With the pandemic likely to continue for 18 months, it is paramount to identify independent risk factors early to facilitate both risk stratification and substantiate necessary triage decisions. \n\nAll patients ≥ 70 years old admitted to ICUs at all participating sites, with proven or suspected COVID-19, will be included in the study. The data collected as part of the treatment of critically ill old patients should help to improve the care of patients with COVID-19 infection worldwide. This application is for the study being undertaken in the UK which will contribute to the larger multinational European study.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
20/SC/0274
Date of REC Opinion
10 Jul 2020
REC opinion
Favourable Opinion