COVID19 clinical predictors and outcome (Version 1.0) [COVID-19]
Research type
Research Study
Full title
COVID-19, clinical predictors and evolution of disease in hospitalised and intensive care patients.
IRAS ID
282942
Contact name
Timothy D Planche
Contact email
Sponsor organisation
St George’s, University of London & St George’s University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 11 months, 16 days
Research summary
In December 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, Hubei, China, and now spreads across international borders. As of 11 April 2020, the total global number of confirmed SARS-CoV-2 cases reached 1,521,252 (92,798 deaths); with 65,081 (7,978 deaths) being reported in the United Kingdom.\n\nCOVID-19 is the name of the disease associated with SARS-CoV-2 infection and includes a spectrum of illness that ranges from mild infection to severe pneumonia that can progress to respiratory failure and Acute Respiratory Distress Syndrome (ARDS) or septic shock. Between 8 to 15% (depending on geographical setting) of all SARS-CoV-2 positive cases can be classified as severe or necessitating intensive care unit (ICU) admission. \n\nIn the early stages of the outbreak unfolding, several retrospective case studies and cases series carried out in China reported that those who died were more likely to be male, and more likely to have underlying comorbidities. Prevalence studies conducted in the US and Italy show similar trends in the distribution of comorbidities among SARS-CoV-2 severe cases; adding obesity (BMI>30) to the list of factors potentially associated with disease severity. However, the relative importance of different underlying health conditions remains unclear owing to inadequate adjustment for important confounding factors such as age, sex, and smoking status. \n\nWe propose a cohort study to evaluate predictors, clinical evolution and excess of mortality of SARS-CoV-2 in hospitalised patients, with two main workstreams- the first looking at all patients admitted to SGHFT and the second looking at patients admitted to ITU with respiratory failure. \n
REC name
South Central - Oxford B Research Ethics Committee
REC reference
20/SC/0220
Date of REC Opinion
3 Jun 2020
REC opinion
Favourable Opinion