COVID-19 Post-Mortem Evaluation (COPE Study) [COVID-19]

• Research type

  Research Study

• Full title

  Use of Post-Mortem Examination Tissue and Organs for Research in Patients with COVID-19

• IRAS ID

  285857

• Contact name

  David K Menon

• Contact email

  dkm13@cam.ac.uk

• Sponsor organisation

  Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge

• Duration of Study in the UK

  3 years, 0 months, 1 days

• Research summary

  Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emerged coronavirus (SARSCoV-2). While most people with COVID-19 develop only mild self-limiting illness, approximately 14% develop severe pneumonitis that requires hospitalisation and oxygen support. About 5% require admission to an intensive care unit for ventilatory support. In severe cases, COVID-19 can be complicated by ARDS, septic shock, and multiorgan failure including kidney, liver and cardiac injury. In these severely affected patients requiring invasive mechanical ventilation on an ICU, the mortality remains high (up to 50%).

  There is an increasing recognition that post-mortem examinations may provide a distinctive (and otherwise inaccessible) perspective on pathogenesis and pathology. This study aims to obtain consent for research use of tissues, biosamples and organs that are obtained at coronial or hospital post-mortem.

• REC name

  West Midlands - Black Country Research Ethics Committee

• REC reference

  20/WM/0270

• Date of REC Opinion

  28 Sep 2020

• REC opinion

  Favourable Opinion