Covid-19 Myocardial Injury Study v1.0 [COVID-19]
Research type
Research Study
Full title
Detection of coronary thrombus and myocardial injury in patients with COVID-19 infection – a pilot study
IRAS ID
283078
Contact name
Tushar Kotecha
Contact email
Sponsor organisation
Royal Free London NHS Foundation Trust
Eudract number
2020-000936-23
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Currently, the COVID-19 pandemic is a worldwide public health emergency that has resulted in a significant number of deaths. Early reports suggested that 10-20% of those infected had elevated levels of troponin, which is a sensitive blood marker for injury or damage to the heart muscle. It has been shown that patients with COVID-19 and a high troponin level are more likely to die but it is unclear why this enzyme is elevated with COVID-19 infection. The plan to investigate patients with acute COVID-19 infection and those that have recovered from COVID-19 infection in order to assess for injury to the heart.\n\nPossible explanations are inflammation in the heart or development of small clots within the heart arteries. The aim of this study is understand the mechanisms of heart damage in COVID-19 infection by assessing a small group of patients with COVID-19 infection and troponin rise to look for clots within the heart arteries (using a special imaging catheter during a coronary angiogram procedure) and assessing for heart muscle damage using cardiovascular magnetic resonance (CMR) scanning. We believe this information will help us to understand the mechanisms of heart damage in these patients with a view to enabling doctors to provide targeted treatment to reduce damage according to the causes identified. \n\n\n [Study relying on COPI notice]
REC name
HSC REC B
REC reference
20/NI/0064
Date of REC Opinion
15 May 2020
REC opinion
Further Information Favourable Opinion